6515.2:
Design of peptidic nanoparticles as drug targeting systems for the treatment of cancer (Proof of concept)
Abstract
We have recently de novo designed self-assembling peptidic nanoparticles with a diameter of about 17 nm. We propose to functionalize these nanoparticles for the transport of radionuclides to a target cancer cell, by attaching a targeting unit as well as a chelator to the peptide chain, the building block of these nanoparticles. The targeting unit octreotide specifically binds to the sstr, which is over-expressed on certain types of cancer cells. With the chelator DOTA binding a radionuclide, this nanoparticle will be used as a drug delivery system for the transport of radionuclides to cancer cells.