5601.1:
Wound Pads Healing with Novel Antibacterial Nano-scale Particles
Abstract
TISSUPOR AG of St Gallen, Switzerland has recently developed healing pads consisting of polyamide blended polyester for wound treatment. A collaboration between the EPFL and TISSUPOR AG intends to incorporate on the TISSUPOR textile nano-sized TiO2 and evaluate its antibacterial activity in the presence of daylight and air (O2). The TiO2 will be prepared a) from sol-gel coating "in situ" TiO2 or b) or from previously made titanium powder. To affect disinfection in the dark Ag2O or CuO (Cu1+) nano-clusters will be incorporated in the second part of the project since these are known disinfectant agents active in the absence of light. Work will focus on the immobilization process of TiO2 on the textile surface through a) electrostatic attraction of the textile or the derivatized textile surface with sulfonic groups and b) covalent bonding trough cyanuric chlorides. The amount of TiO2 incorporated will be determined by adsorption experiments, electron microscopy and electrophoresis. The nature and size of the most active TiO2 incorporated on the textile will be analyzed by X-ray diffraction, Infrared spectroscopy (TFIR), XPS, EM and Mössbauer spectroscopy. The activity and stability of the catalytic deposits will be evaluated in conjunction with TISSUPOR AG.