6358.1:
Experiment-guided computational simulation techniques for the modeling of mammalian organogenesis in vitro: Analysis of nano-forces and morphological changes during organogenesis
Abstract
We apply a dual investigation strategy to the problem of organogenesis, with a focus on nanoscale force and cell extension formation. We conduct simultaneously experiments of 3D in vitro renal cysto- and tubulogenesis, and we develop a computational platform to study the same processes. This experimental-computational synergy allows for the development of a simulation model guided by the experimental insight and for the conduction of focused experiments to answer particular simulation-oriented questions. Finally we might be able to delineate reasons for the high fidelity of reproduction of organ shapes, size and function.